Enhanced bypass of PD-L1 translation reduces the therapeutic response to mTOR kinase inhibitors

Increased PD-L1 expression in cancer cells is known to enhance immunosuppression, but the mechanism underlying PD-L1 upregulation is incompletely characterized. We show that PD-L1 expression is upregulated through internal ribosomal entry site (IRES)-mediated translation upon mTORC1 inhibition. We i...

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Detalles Bibliográficos
Autores principales: Cao, Yanan, Ye, Qing, Ma, Murong, She, Qing-Bai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491412/
https://www.ncbi.nlm.nih.gov/pubmed/37405918
http://dx.doi.org/10.1016/j.celrep.2023.112764

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491412/
https://www.ncbi.nlm.nih.gov/pubmed/37405918
http://dx.doi.org/10.1016/j.celrep.2023.112764

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