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Enhanced bypass of PD-L1 translation reduces the therapeutic response to mTOR kinase inhibitors
Increased PD-L1 expression in cancer cells is known to enhance immunosuppression, but the mechanism underlying PD-L1 upregulation is incompletely characterized. We show that PD-L1 expression is upregulated through internal ribosomal entry site (IRES)-mediated translation upon mTORC1 inhibition. We i...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491412/ https://www.ncbi.nlm.nih.gov/pubmed/37405918 http://dx.doi.org/10.1016/j.celrep.2023.112764 |