PG545 sensitizes ovarian cancer cells to PARP inhibitors through modulation of RAD51-DEK interaction

PG545 (Pixatimod) is a highly sulfated small molecule known for its ability to inhibit heparanase and disrupt signaling mediated by heparan-binding-growth factors (HB-GF). Previous studies indicated that PG545 inhibits growth factor-mediated signaling in ovarian cancer (OC) to enhance response to ch...

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Detalles Bibliográficos
Autores principales: Ray, Upasana, Thirusangu, Prabhu, Jin, Ling, Xiao, Yinan, Pathoulas, Christopher L., Staub, Julie, Erskine, Courtney L., Dredge, Keith, Hammond, Edward, Block, Matthew S., Kaufmann, Scott H., Bakkum-Gamez, Jamie N., Shridhar, Viji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491494/
https://www.ncbi.nlm.nih.gov/pubmed/37550562
http://dx.doi.org/10.1038/s41388-023-02785-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491494/
https://www.ncbi.nlm.nih.gov/pubmed/37550562
http://dx.doi.org/10.1038/s41388-023-02785-5

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