Activation of the integrated stress response by inhibitors of its kinases

Phosphorylation of the translation initiation factor eIF2α to initiate the integrated stress response (ISR) is a vital signalling event. Protein kinases activating the ISR, including PERK and GCN2, have attracted considerable attention for drug development. Here we find that the widely used ATP-comp...

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Detalles Bibliográficos
Autores principales: Szaruga, Maria, Janssen, Dino A., de Miguel, Claudia, Hodgson, George, Fatalska, Agnieszka, Pitera, Aleksandra P., Andreeva, Antonina, Bertolotti, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491595/
https://www.ncbi.nlm.nih.gov/pubmed/37684277
http://dx.doi.org/10.1038/s41467-023-40823-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491595/
https://www.ncbi.nlm.nih.gov/pubmed/37684277
http://dx.doi.org/10.1038/s41467-023-40823-8

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