A strategy for Cas13 miniaturization based on the structure and AlphaFold

The small size of the Cas nuclease fused with various effector domains enables a broad range of function. Although there are several ways of reducing the size of the Cas nuclease complex, no efficient or generalizable method has been demonstrated to achieve protein miniaturization. In this study, we...

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Detalles Bibliográficos
Autores principales: Zhao, Feiyu, Zhang, Tao, Sun, Xiaodi, Zhang, Xiyun, Chen, Letong, Wang, Hejun, Li, Jinze, Fan, Peng, Lai, Liangxue, Sui, Tingting, Li, Zhanjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491665/
https://www.ncbi.nlm.nih.gov/pubmed/37684268
http://dx.doi.org/10.1038/s41467-023-41320-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491665/
https://www.ncbi.nlm.nih.gov/pubmed/37684268
http://dx.doi.org/10.1038/s41467-023-41320-8

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