Intracellular BAPTA directly inhibits PFKFB3, thereby impeding mTORC1-driven Mcl-1 translation and killing MCL-1-addicted cancer cells

Intracellular Ca(2+) signals control several physiological and pathophysiological processes. The main tool to chelate intracellular Ca(2+) is intracellular BAPTA (BAPTA(i)), usually introduced into cells as a membrane-permeant acetoxymethyl ester (BAPTA-AM). Previously, we demonstrated that BAPTA(i)...

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Detalles Bibliográficos
Autores principales: Sneyers, Flore, Kerkhofs, Martijn, Speelman-Rooms, Femke, Welkenhuyzen, Kirsten, La Rovere, Rita, Shemy, Ahmed, Voet, Arnout, Eelen, Guy, Dewerchin, Mieke, Tait, Stephen W. G., Ghesquière, Bart, Bootman, Martin D., Bultynck, Geert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491774/
https://www.ncbi.nlm.nih.gov/pubmed/37684238
http://dx.doi.org/10.1038/s41419-023-06120-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491774/
https://www.ncbi.nlm.nih.gov/pubmed/37684238
http://dx.doi.org/10.1038/s41419-023-06120-4

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