PARP inhibitors: enhancing efficacy through rational combinations

Poly (ADP-ribose) polymerase inhibitors (PARPi) have significantly changed the treatment landscape for tumours harbouring defects in genes involved in homologous repair (HR) such as BRCA1 and BRCA2. Despite initial responsiveness to PARPi, tumours eventually develop resistance through a variety of m...

Descripción completa

Detalles Bibliográficos
Autores principales: Bhamidipati, Deepak, Haro-Silerio, Jaime I., Yap, Timothy A., Ngoi, Natalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491787/
https://www.ncbi.nlm.nih.gov/pubmed/37430137
http://dx.doi.org/10.1038/s41416-023-02326-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491787/
https://www.ncbi.nlm.nih.gov/pubmed/37430137
http://dx.doi.org/10.1038/s41416-023-02326-7

Ejemplares similares