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Structures of liganded glycosylphosphatidylinositol transamidase illuminate GPI-AP biogenesis

Many eukaryotic receptors and enzymes rely on glycosylphosphatidylinositol (GPI) anchors for membrane localization and function. The transmembrane complex GPI-T recognizes diverse proproteins at a signal peptide region that lacks consensus sequence and replaces it with GPI via a transamidation react...

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Detalles Bibliográficos
Autores principales: Xu, Yidan, Li, Tingting, Zhou, Zixuan, Hong, Jingjing, Chao, Yulin, Zhu, Zhini, Zhang, Ying, Qu, Qianhui, Li, Dianfan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491789/
https://www.ncbi.nlm.nih.gov/pubmed/37684232
http://dx.doi.org/10.1038/s41467-023-41281-y