Structural dynamics influences the antibacterial activity of a cell-penetrating peptide (KFF)(3)K

Given the widespread demand for novel antibacterial agents, we modified a cell-penetrating peptide (KFF)(3)K to transform it into an antibacterial peptide. Namely, we inserted a hydrocarbon staple into the (KFF)(3)K sequence to induce and stabilize its membrane-active secondary structure. The staple...

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Detalles Bibliográficos
Autores principales: Macyszyn, Julia, Chyży, Piotr, Burmistrz, Michał, Lobka, Małgorzata, Miszkiewicz, Joanna, Wojciechowska, Monika, Trylska, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491836/
https://www.ncbi.nlm.nih.gov/pubmed/37684254
http://dx.doi.org/10.1038/s41598-023-38745-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491836/
https://www.ncbi.nlm.nih.gov/pubmed/37684254
http://dx.doi.org/10.1038/s41598-023-38745-y

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