Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS/STING signaling dependent on LKB1/AMPK/ULK1-mediated autophagy

INTRODUCTION: Meteorin-like hormone (Metrnl) is ubiquitously expressed in skeletal muscle, heart, and adipose with beneficial roles in obesity, insulin resistance, and inflammation. Metrnl is found to protect against cardiac hypertrophy and doxorubicin-induced cardiotoxicity. However, its role in di...

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Detalles Bibliográficos
Autores principales: Lu, Qing-Bo, Ding, Yi, Liu, Yao, Wang, Zi-Chao, Wu, Yu-Jie, Niu, Kai-Ming, Li, Ke-Xue, Zhang, Ji-Ru, Sun, Hai-Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491969/
https://www.ncbi.nlm.nih.gov/pubmed/36334887
http://dx.doi.org/10.1016/j.jare.2022.10.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491969/
https://www.ncbi.nlm.nih.gov/pubmed/36334887
http://dx.doi.org/10.1016/j.jare.2022.10.014

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