Thioredoxin-interacting protein-activated intracellular potassium deprivation mediates the anti-tumour effect of a novel histone acetylation inhibitor HL23, a fangchinoline derivative, in human hepatocellular carcinoma

INTRODUCTION: Hyperactivated histone deacetylases (HDACs) act as epigenetic repressors on gene transcription and are frequently observed in human hepatocellular carcinoma (HCC). Although multiple pharmacological HDAC inhibitors (HDACis) have been developed, none is available in human HCC. OBJECTIVES...

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Detalles Bibliográficos
Autores principales: Lu, Yuanjun, Liu, Yazhou, Lan, Junjie, Chan, Yau-Tuen, Feng, Zixin, Huang, Lan, Wang, Ning, Pan, Weidong, Feng, Yibin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491973/
https://www.ncbi.nlm.nih.gov/pubmed/36351536
http://dx.doi.org/10.1016/j.jare.2022.10.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491973/
https://www.ncbi.nlm.nih.gov/pubmed/36351536
http://dx.doi.org/10.1016/j.jare.2022.10.017

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