Impaired autophagy contributes to the aggravated deterioration of osteoarthritis articular cartilage by peroxisome proliferator-activated receptor α deficiency, associated with decreased ERK and Akt activation

BACKGROUND: Although the chondroprotection of peroxisome proliferator-activated receptor α (PPARα) activation against osteoarthritis (OA) has been revealed, the regulatory mechanism of PPARα deficiency to aggravate osteoarthritic cartilage deterioration remains unclear. Here, we aimed to investigate...

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Detalles Bibliográficos
Autores principales: Zhou, Yang, Li, Li, Chen, Xiaolei, Zhao, Qiubo, Qu, Ning, Zhang, Bing, Jin, Xin, Xia, Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492277/
https://www.ncbi.nlm.nih.gov/pubmed/37689723
http://dx.doi.org/10.1186/s40001-023-01267-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492277/
https://www.ncbi.nlm.nih.gov/pubmed/37689723
http://dx.doi.org/10.1186/s40001-023-01267-4

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