Energetics and dynamics of the proton shuttle of carbonic anhydrase II

Human carbonic anhydrase II catalyzes the reversible reaction of carbon dioxide and water to form bicarbonate and a proton. His64-mediated proton shuttling between the active site and the bulk solvent is rate limiting. Here we investigate the protonation behavior of His64 as well as its structural a...

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Detalles Bibliográficos
Autores principales: Raum, Heiner N., Fisher, Suzanne Zoë, Weininger, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492700/
https://www.ncbi.nlm.nih.gov/pubmed/37688664
http://dx.doi.org/10.1007/s00018-023-04936-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492700/
https://www.ncbi.nlm.nih.gov/pubmed/37688664
http://dx.doi.org/10.1007/s00018-023-04936-z

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