Synapses do not facilitate prion-like transfer of alpha-synuclein: a quantitative study in reconstructed unidirectional neural networks

Alpha-synuclein (aSyn) aggregation spreads between cells and underlies the progression of neuronal lesions in the brain of patients with synucleinopathies such as Parkinson’s diseases. The mechanisms of cell-to-cell propagation of aggregates, which dictate how aggregation progresses at the network l...

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Detalles Bibliográficos
Autores principales: Courte, Josquin, Le, Ngoc Anh, Pan, Teng, Bousset, Luc, Melki, Ronald, Villard, Catherine, Peyrin, Jean-Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492778/
https://www.ncbi.nlm.nih.gov/pubmed/37688644
http://dx.doi.org/10.1007/s00018-023-04915-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492778/
https://www.ncbi.nlm.nih.gov/pubmed/37688644
http://dx.doi.org/10.1007/s00018-023-04915-4

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