Epidemiological and molecular characterization of HBV and HCV infections in HIV-1-infected inmate population in Italy: a 2017–2019 multicenter cross-sectional study

HBV/HCV co-infection is common in HIV-1-infected prisoners. To investigate the characteristics of HIV co-infections, and to evaluate the molecular heterogeneity of HIV, HBV and HCV in prisoners, we carried-out a multicenter cross-sectional study, including 65 HIV-1-infected inmates enrolled in 5 Ita...

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Autores principales: Maggiorella, Maria Teresa, Sernicola, L., Picconi, O., Pizzi, E., Belli, R., Fulgenzi, D., Rovetto, C., Bruni, R., Costantino, A., Taffon, S., Chionne, P., Madonna, E., Pisani, G., Borsetti, A., Falvino, C., Ranieri, R., Baccalini, R., Pansera, A., Castelvedere, F., Babudieri, S., Madeddu, G., Starnini, G., Dell’Isola, S., Cervellini, P., Ciccaglione, A. R., Ensoli, B., Buttò, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492787/
https://www.ncbi.nlm.nih.gov/pubmed/37689795
http://dx.doi.org/10.1038/s41598-023-41814-x
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author Maggiorella, Maria Teresa
Sernicola, L.
Picconi, O.
Pizzi, E.
Belli, R.
Fulgenzi, D.
Rovetto, C.
Bruni, R.
Costantino, A.
Taffon, S.
Chionne, P.
Madonna, E.
Pisani, G.
Borsetti, A.
Falvino, C.
Ranieri, R.
Baccalini, R.
Pansera, A.
Castelvedere, F.
Babudieri, S.
Madeddu, G.
Starnini, G.
Dell’Isola, S.
Cervellini, P.
Ciccaglione, A. R.
Ensoli, B.
Buttò, S.
author_facet Maggiorella, Maria Teresa
Sernicola, L.
Picconi, O.
Pizzi, E.
Belli, R.
Fulgenzi, D.
Rovetto, C.
Bruni, R.
Costantino, A.
Taffon, S.
Chionne, P.
Madonna, E.
Pisani, G.
Borsetti, A.
Falvino, C.
Ranieri, R.
Baccalini, R.
Pansera, A.
Castelvedere, F.
Babudieri, S.
Madeddu, G.
Starnini, G.
Dell’Isola, S.
Cervellini, P.
Ciccaglione, A. R.
Ensoli, B.
Buttò, S.
author_sort Maggiorella, Maria Teresa
collection PubMed
description HBV/HCV co-infection is common in HIV-1-infected prisoners. To investigate the characteristics of HIV co-infections, and to evaluate the molecular heterogeneity of HIV, HBV and HCV in prisoners, we carried-out a multicenter cross-sectional study, including 65 HIV-1-infected inmates enrolled in 5 Italian detention centers during the period 2017–2019. HIV-1 subtyping showed that 77.1% of inmates were infected with B subtype and 22.9% with non-B subtypes. Italian nationals were all infected with subtype B (93.1%), except two individuals, one infected with the recombinant form CRF72_BF1, and the other with the HIV-1 sub-subtype A6, both previously not identified in inmates of Italian nationality. Non-Italian nationals were infected with subtype B (52.6%), CRFs (36.8%) and sub-subtypes A1 and A3 (5.2%). HIV variants carrying resistance mutations to NRTI, NNRTI, PI and InSTI were found in 7 inmates, 4 of which were never exposed to the relevant classes of drugs associated with these mutations. HBV and/or HCV co-infections markers were found in 49/65 (75.4%) inmates, while 27/65 (41.5%) showed markers of both HBV and HCV coinfection. Further, Italian nationals showed a significant higher presence of HCV markers as compared to non-Italian nationals (p = 0.0001). Finally, HCV phylogenetic analysis performed in 18 inmates revealed the presence of HCV subtypes 1a, 3a, 4d (66.6%, 16.7% and 16.7%, respectively). Our data suggest the need to monitor HIV, HBV and HCV infections in prisons in order to prevent spreading of these viruses both in jails and in the general population, and to implement effective public health programs that limit the circulation of different genetic forms as well as of viral variants with mutations conferring resistance to treatment.
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spelling pubmed-104927872023-09-11 Epidemiological and molecular characterization of HBV and HCV infections in HIV-1-infected inmate population in Italy: a 2017–2019 multicenter cross-sectional study Maggiorella, Maria Teresa Sernicola, L. Picconi, O. Pizzi, E. Belli, R. Fulgenzi, D. Rovetto, C. Bruni, R. Costantino, A. Taffon, S. Chionne, P. Madonna, E. Pisani, G. Borsetti, A. Falvino, C. Ranieri, R. Baccalini, R. Pansera, A. Castelvedere, F. Babudieri, S. Madeddu, G. Starnini, G. Dell’Isola, S. Cervellini, P. Ciccaglione, A. R. Ensoli, B. Buttò, S. Sci Rep Article HBV/HCV co-infection is common in HIV-1-infected prisoners. To investigate the characteristics of HIV co-infections, and to evaluate the molecular heterogeneity of HIV, HBV and HCV in prisoners, we carried-out a multicenter cross-sectional study, including 65 HIV-1-infected inmates enrolled in 5 Italian detention centers during the period 2017–2019. HIV-1 subtyping showed that 77.1% of inmates were infected with B subtype and 22.9% with non-B subtypes. Italian nationals were all infected with subtype B (93.1%), except two individuals, one infected with the recombinant form CRF72_BF1, and the other with the HIV-1 sub-subtype A6, both previously not identified in inmates of Italian nationality. Non-Italian nationals were infected with subtype B (52.6%), CRFs (36.8%) and sub-subtypes A1 and A3 (5.2%). HIV variants carrying resistance mutations to NRTI, NNRTI, PI and InSTI were found in 7 inmates, 4 of which were never exposed to the relevant classes of drugs associated with these mutations. HBV and/or HCV co-infections markers were found in 49/65 (75.4%) inmates, while 27/65 (41.5%) showed markers of both HBV and HCV coinfection. Further, Italian nationals showed a significant higher presence of HCV markers as compared to non-Italian nationals (p = 0.0001). Finally, HCV phylogenetic analysis performed in 18 inmates revealed the presence of HCV subtypes 1a, 3a, 4d (66.6%, 16.7% and 16.7%, respectively). Our data suggest the need to monitor HIV, HBV and HCV infections in prisons in order to prevent spreading of these viruses both in jails and in the general population, and to implement effective public health programs that limit the circulation of different genetic forms as well as of viral variants with mutations conferring resistance to treatment. Nature Publishing Group UK 2023-09-09 /pmc/articles/PMC10492787/ /pubmed/37689795 http://dx.doi.org/10.1038/s41598-023-41814-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Maggiorella, Maria Teresa
Sernicola, L.
Picconi, O.
Pizzi, E.
Belli, R.
Fulgenzi, D.
Rovetto, C.
Bruni, R.
Costantino, A.
Taffon, S.
Chionne, P.
Madonna, E.
Pisani, G.
Borsetti, A.
Falvino, C.
Ranieri, R.
Baccalini, R.
Pansera, A.
Castelvedere, F.
Babudieri, S.
Madeddu, G.
Starnini, G.
Dell’Isola, S.
Cervellini, P.
Ciccaglione, A. R.
Ensoli, B.
Buttò, S.
Epidemiological and molecular characterization of HBV and HCV infections in HIV-1-infected inmate population in Italy: a 2017–2019 multicenter cross-sectional study
title Epidemiological and molecular characterization of HBV and HCV infections in HIV-1-infected inmate population in Italy: a 2017–2019 multicenter cross-sectional study
title_full Epidemiological and molecular characterization of HBV and HCV infections in HIV-1-infected inmate population in Italy: a 2017–2019 multicenter cross-sectional study
title_fullStr Epidemiological and molecular characterization of HBV and HCV infections in HIV-1-infected inmate population in Italy: a 2017–2019 multicenter cross-sectional study
title_full_unstemmed Epidemiological and molecular characterization of HBV and HCV infections in HIV-1-infected inmate population in Italy: a 2017–2019 multicenter cross-sectional study
title_short Epidemiological and molecular characterization of HBV and HCV infections in HIV-1-infected inmate population in Italy: a 2017–2019 multicenter cross-sectional study
title_sort epidemiological and molecular characterization of hbv and hcv infections in hiv-1-infected inmate population in italy: a 2017–2019 multicenter cross-sectional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492787/
https://www.ncbi.nlm.nih.gov/pubmed/37689795
http://dx.doi.org/10.1038/s41598-023-41814-x
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