A Bischler-Napieralski and homo-Mannich sequence enables diversified syntheses of sarpagine alkaloids and analogues

Sarpagine alkaloids offer signicant opportunities in drug discovery, yet the efficient total syntheses and diverse structural modifications of these natural products remain highly challenging due to the architectural complexity. Here we show a homo-Mannich reaction of cyclopropanol with imines gener...

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Detalles Bibliográficos
Autores principales: Qiu, Hanyue, Fei, Xinghai, Yang, Jiaojiao, Qiao, Zhen, Yuan, Shan, Zhang, Hu, He, Ling, Zhang, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492809/
https://www.ncbi.nlm.nih.gov/pubmed/37689783
http://dx.doi.org/10.1038/s41467-023-41268-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492809/
https://www.ncbi.nlm.nih.gov/pubmed/37689783
http://dx.doi.org/10.1038/s41467-023-41268-9

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