Cargando…

A Bischler-Napieralski and homo-Mannich sequence enables diversified syntheses of sarpagine alkaloids and analogues

Sarpagine alkaloids offer signicant opportunities in drug discovery, yet the efficient total syntheses and diverse structural modifications of these natural products remain highly challenging due to the architectural complexity. Here we show a homo-Mannich reaction of cyclopropanol with imines gener...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qiu, Hanyue, Fei, Xinghai, Yang, Jiaojiao, Qiao, Zhen, Yuan, Shan, Zhang, Hu, He, Ling, Zhang, Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492809/ https://www.ncbi.nlm.nih.gov/pubmed/37689783 http://dx.doi.org/10.1038/s41467-023-41268-9

Ejemplares similares

Synthesis of Carbazoles by a Diverted Bischler–Napieralski Cascade Reaction
por: Faltracco, Matteo, et al.
Publicado: (2021)

Synthesis of tetracyclic spiroindolines by an interrupted Bischler–Napieralski reaction: total synthesis of akuammicine
por: Faltracco, Matteo, et al.
Publicado: (2021)

Structure units oriented approach towards collective synthesis of sarpagine-ajmaline-koumine type alkaloids
por: Chen, Wen, et al.
Publicado: (2022)

Three-component radical homo Mannich reaction
por: Shi, Shuai, et al.
Publicado: (2021)

Synthesis of Bisindole Alkaloids from the Apocynaceae Which Contain a Macroline or Sarpagine Unit: A Review
por: Rahman, Md Toufiqur, et al.
Publicado: (2016)

HFIP-Promoted Bischler Indole Synthesis under Microwave Irradiation
por: Yao, Guangkai, et al.
Publicado: (2018)

Completion of the Total Synthesis of Several Bioactive Sarpagine/Macroline Alkaloids including the Important NF-κB Inhibitor N(4)-Methyltalpinine
por: Rahman, Md Toufiqur, et al.
Publicado: (2022)

Mannich base-connected syntheses mediated by ortho-quinone methides
por: Barta, Petra, et al.
Publicado: (2018)

Deploying Microbial Synthesis for Halogenating and Diversifying Medicinal Alkaloid Scaffolds
por: Bradley, Samuel A., et al.
Publicado: (2020)

Total Syntheses and Preliminary Biological Evaluation of Brominated Fascaplysin and Reticulatine Alkaloids and Their Analogues
por: Zhidkov, Maxim E., et al.
Publicado: (2019)

Newly Synthesized Morpholinyl Mannich Bases as Corrosion Inhibitors for N80 Steel in Acid Environment
por: Chen, Yuhao, et al.
Publicado: (2022)

General Strategy for Synthesis of C-19 Methyl-Substituted Sarpagine/Macroline/Ajmaline Indole Alkaloids Including Total Synthesis of 19(S),20(R)-Dihydroperaksine, 19(S),20(R)-Dihydroperaksine-17-al, and Peraksine
por: Edwankar, Rahul V., et al.
Publicado: (2014)

The Redox-Mannich Reaction
por: Chen, Weijie, et al.
Publicado: (2014)

One-Pot Synthesis of Novel Chiral β-Amino Acid Derivatives by Enantioselective Mannich Reactions Catalyzed by Squaramide Cinchona Alkaloids
por: Zhang, Kankan, et al.
Publicado: (2013)

Studies on the Alkaloids of the Calycanthaceae and Their Syntheses
por: Xu, Jin-Biao, et al.
Publicado: (2015)

Chemical syntheses and salient features of azulene-containing homo- and copolymers
por: Shetti, Vijayendra S
Publicado: (2021)

Copper(I)-catalyzed asymmetric decarboxylative Mannich reaction enabled by acidic activation of 2H-azirines
por: Zhang, Hai-Jun, et al.
Publicado: (2019)

Study of 2-aminoquinolin-4(1H)-one under Mannich and retro-Mannich reaction
por: Funk, Petr, et al.
Publicado: (2017)

Deployment of Sulfinimines in Charge-Accelerated Sulfonium Rearrangement Enables a Surrogate Asymmetric Mannich Reaction
por: Feng, Minghao, et al.
Publicado: (2022)

Catalytic enantioselective reductive alkynylation of amides enables one-pot syntheses of pyrrolidine, piperidine and indolizidine alkaloids
por: Xu, Fang-Fang, et al.
Publicado: (2023)

Syntheses and crystal structures of two adamantyl-substituted 1,2,4-triazole-5-thione N-Mannich bases
por: Al-Alshaikh, Monirah A., et al.
Publicado: (2017)

Convergent syntheses of Le(X) analogues
por: Wang, An, et al.
Publicado: (2010)

Water enables diastereodivergency in bispidine-based chiral amine-catalyzed asymmetric Mannich reaction of cyclic N-sulfonyl ketimines with ketones
por: Li, Gonglin, et al.
Publicado: (2022)

Novel total syntheses of oxoaporphine alkaloids enabled by mild Cu-catalyzed tandem oxidation/aromatization of 1-Bn-DHIQs
por: Zheng, Bo, et al.
Publicado: (2018)

Chiral Lewis acid-bonded picolinaldehyde enables enantiodivergent carbonyl catalysis in the Mannich/condensation reaction of glycine ester
por: Zhong, Xia, et al.
Publicado: (2021)

Studies on the Anthelmintic Property of Aminobenzylated Mannich Bases
por: Chaluvaraju, KC, et al.
Publicado: (2011)

Iridium-Catalyzed Reductive Nitro-Mannich Cyclization
por: Gregory, Alex W, et al.
Publicado: (2015)

Mannich Bases: An Important Pharmacophore in Present Scenario
por: Bala, Suman, et al.
Publicado: (2014)

Mannich bases in medicinal chemistry and drug design
por: Roman, Gheorghe
Publicado: (2015)

Enantio- and diastereoselective conjugate borylation/Mannich cyclization
por: Larin, Egor M., et al.
Publicado: (2020)

Synthesis and Antibacterial Analysis of Analogues of the Marine Alkaloid Pseudoceratidine
por: Barker, David, et al.
Publicado: (2020)

Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR
por: Huang, Xiangchen, et al.
Publicado: (2010)

Cinchona Alkaloid Derivative-Catalyzed Enantioselective Synthesis via a Mannich-Type Reaction and Antifungal Activity of β-Amino Esters Bearing Benzoheterocycle Moieties
por: Xiao, Han, et al.
Publicado: (2014)

Synthesis of glycosylated β(3)-homo-threonine conjugates for mucin-like glycopeptide antigen analogues
por: Karch, Florian, et al.
Publicado: (2010)

Three-center-four-electron halogen bond enables non-metallic complex catalysis for Mukaiyama-Mannich-type reaction
por: Oishi, Shunya, et al.
Publicado: (2022)

Antidepressant Activities of Synthesized Benzodiazepine Analogues in Mice
por: Haq, Faizan Ul, et al.
Publicado: (2023)

Antimicrobial Activity of the Marine Alkaloids, Clathrodin and Oroidin, and Their Synthetic Analogues
por: Zidar, Nace, et al.
Publicado: (2014)

Retraction: The synthesis and biological activity of marine alkaloid derivatives and analogues
por: Zhou, Shiyang, et al.
Publicado: (2021)

Glycerol as an Efficient Medium for the Petasis Borono–Mannich Reaction
por: Rosholm, Tomi, et al.
Publicado: (2015)

Asymmetric Catalytic Ketimine Mannich Reactions and Related Transformations
por: Xu, Changgong, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_1n5e0q30i23f65la9p2qioj5pt