The citrate transporters SLC13A5 and SLC25A1 elicit different metabolic responses and phenotypes in the mouse

Cytosolic citrate is imported from the mitochondria by SLC25A1, and from the extracellular milieu by SLC13A5. In the cytosol, citrate is used by ACLY to generate acetyl-CoA, which can then be exported to the endoplasmic reticulum (ER) by SLC33A1. Here, we report the generation of mice with systemic...

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Detalles Bibliográficos
Autores principales: Fernandez-Fuente, Gonzalo, Overmyer, Katherine A., Lawton, Alexis J., Kasza, Ildiko, Shapiro, Samantha L., Gallego-Muñoz, Patricia, Coon, Joshua J., Denu, John M., Alexander, Caroline M., Puglielli, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492862/
https://www.ncbi.nlm.nih.gov/pubmed/37689798
http://dx.doi.org/10.1038/s42003-023-05311-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492862/
https://www.ncbi.nlm.nih.gov/pubmed/37689798
http://dx.doi.org/10.1038/s42003-023-05311-1

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