Prime editor‐mediated functional reshaping of ACE2 prevents the entry of multiple human coronaviruses, including SARS‐CoV‐2 variants

The spike protein of SARS‐CoV‐2 hijacks the host angiotensin converting enzyme 2 (ACE2) to meditate its entry and is the primary target for vaccine development. Nevertheless, SARS‐CoV‐2 keeps evolving and the latest Omicron subvariants BQ.1 and XBB have gained exceptional immune evasion potential th...

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Detalles Bibliográficos
Autores principales: Zhao, Wenwen, Li, Jifang, Wang, Xiao, Xu, Wei, Gao, Bao‐Qing, Xiang, Jiangchao, Hou, Yaofeng, Liu, Wei, Wu, Jing, Qi, Qilian, Wei, Jia, Yang, Xiaoyu, Lu, Lu, Yang, Li, Chen, Jia, Yang, Bei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492923/
https://www.ncbi.nlm.nih.gov/pubmed/37701533
http://dx.doi.org/10.1002/mco2.356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492923/
https://www.ncbi.nlm.nih.gov/pubmed/37701533
http://dx.doi.org/10.1002/mco2.356

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