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Establishment of a sensitive UPLC-MS/MS method to quantify safinamide in rat plasma

A fast, simple, and sensitive ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method was established for the quantification of safinamide in rat plasma. Plasma samples were treated with acetonitrile for protein precipitation, and diazepam was used as an internal standar...

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Detalles Bibliográficos
Autores principales: Wang, Ying, Zhao, Guan-An, Li, Xia, Zhang, En, Tan, Wei, Chen, Jia-qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493267/
https://www.ncbi.nlm.nih.gov/pubmed/37701033
http://dx.doi.org/10.3389/fphar.2023.1211383