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Identification and characterization of a novel chromosomal aminoglycoside 3’-O-phosphotransferase, APH(3′)-Id, from Kluyvera intermedia DW18 isolated from the sewage of an animal farm

BACKGROUND: Aminoglycosides, as important clinical antimicrobials, are used as second-line drugs for treating multidrug-resistant tuberculosis or combined with β-lactam drugs for treating severe infections such as sepsis. Aminoglycoside-modifying enzyme (AME) is the most important mechanism of amino...

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Detalles Bibliográficos
Autores principales: Sha, Yuning, Lin, Naru, Zhang, Guozhi, Zhang, Yuan, Zhao, Jingxuan, Lu, Junwan, Zhu, Tingting, Zhang, Xueya, Li, Qiaoling, Zhang, Hailin, Lin, Xi, Li, Kewei, Bao, Qiyu, Li, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493288/
https://www.ncbi.nlm.nih.gov/pubmed/37700861
http://dx.doi.org/10.3389/fmicb.2023.1224464