Pharmacokinetics of mebendazole in plasma and cerebrospinal fluid following a single oral dose in healthy dogs

Novel therapies are needed for treatment of gliomas. Mebendazole previously demonstrated anti-neoplastic effects on canine glioma cell lines at in vitro mean inhibitory concentrations (IC(50)) of 10 ng/mL. Our study aimed to titrate the oral dose of mebendazole necessary to achieve concentrations ≥1...

Descripción completa

Detalles Bibliográficos
Autores principales: Yanke, Amy B., Day, Kendall E., Taylor, Amanda R., Cruz-Espindola, Crisanta, Boothe, Dawn M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Veterinary Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493385/
https://www.ncbi.nlm.nih.gov/pubmed/37701529
http://dx.doi.org/10.3389/fvets.2023.1231769

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493385/
https://www.ncbi.nlm.nih.gov/pubmed/37701529
http://dx.doi.org/10.3389/fvets.2023.1231769

Ejemplares similares