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Pharmacokinetics of mebendazole in plasma and cerebrospinal fluid following a single oral dose in healthy dogs

Novel therapies are needed for treatment of gliomas. Mebendazole previously demonstrated anti-neoplastic effects on canine glioma cell lines at in vitro mean inhibitory concentrations (IC(50)) of 10 ng/mL. Our study aimed to titrate the oral dose of mebendazole necessary to achieve concentrations ≥1...

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Detalles Bibliográficos
Autores principales:	Yanke, Amy B., Day, Kendall E., Taylor, Amanda R., Cruz-Espindola, Crisanta, Boothe, Dawn M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Veterinary Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493385/ https://www.ncbi.nlm.nih.gov/pubmed/37701529 http://dx.doi.org/10.3389/fvets.2023.1231769

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