Degradation of NLRP3 by p62‐dependent‐autophagy improves cognitive function in Alzheimer's disease by maintaining the phagocytic function of microglia

BACKGROUND: Activation of the NLRP3 inflammasome promotes microglia to secrete inflammatory cytokines and induce pyroptosis, leading to impaired phagocytic and clearance functions of microglia in Alzheimer's disease (AD). This study found that the autophagy‐associated protein p62 interacts with...

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Detalles Bibliográficos
Autores principales: Zhang, Dongyuan, Zhang, Yu, Pan, Jirong, Cao, Jingjing, Sun, Xiuping, Li, Xianglei, Zhang, Ling, Qin, Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493665/
https://www.ncbi.nlm.nih.gov/pubmed/37072933
http://dx.doi.org/10.1111/cns.14219

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493665/
https://www.ncbi.nlm.nih.gov/pubmed/37072933
http://dx.doi.org/10.1111/cns.14219

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