Cargando…

Elamipretide reduces pyroptosis and improves functional recovery after spinal cord injury

AIMS: Elamipretide (EPT), a novel mitochondria‐targeted peptide, has been shown to be protective in a range of diseases. However, the effect of EPT in spinal cord injury (SCI) has yet to be elucidated. We aimed to investigate whether EPT would inhibit pyroptosis and protect against SCI. METHODS: Aft...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Wu, He, Fan, Ding, Guoming, Wu, Junsong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493668/ https://www.ncbi.nlm.nih.gov/pubmed/37081763 http://dx.doi.org/10.1111/cns.14221

Ejemplares similares

Elamipretide alleviates pyroptosis in traumatically injured spinal cord by inhibiting cPLA2-induced lysosomal membrane permeabilization
por: Zhang, Haojie, et al.
Publicado: (2023)

Elamipretide Attenuates Pyroptosis and Perioperative Neurocognitive Disorders in Aged Mice
por: Zuo, Youmei, et al.
Publicado: (2020)

Pyroptosis in spinal cord injury
por: Yin, Jian, et al.
Publicado: (2022)

Role of Pyroptosis in Traumatic Brain and Spinal Cord Injuries
por: Hu, Xinli, et al.
Publicado: (2020)

Role of pyroptosis in spinal cord injury and its therapeutic implications
por: Al Mamun, Abdullah, et al.
Publicado: (2020)

Elamipretide Improves Mitochondrial Function in the Failing Human Heart
por: Chatfield, Kathryn C., et al.
Publicado: (2019)

Treg cell-derived exosomes miR-709 attenuates microglia pyroptosis and promotes motor function recovery after spinal cord injury
por: Xiong, Wu, et al.
Publicado: (2022)

Lithium promotes recovery after spinal cord injury
por: Zhao, Ying-Jie, et al.
Publicado: (2021)

Paclitaxel-incorporated nanoparticles improve functional recovery after spinal cord injury
por: Zhang, Xinzhu, et al.
Publicado: (2022)

Subcutaneous Administration of PDGF-AA Improves the Functional Recovery After Spinal Cord Injury
por: Guo, Xue-Yan, et al.
Publicado: (2019)

Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury
por: Dias, David Oliveira, et al.
Publicado: (2018)

Statin use is associated with reduced motor recovery after spinal cord injury
por: Triplet, Erin M., et al.
Publicado: (2021)

Barth syndrome cardiomyopathy: targeting the mitochondria with elamipretide
por: Sabbah, Hani N.
Publicado: (2020)

Elamipretide mitigates ischemia-reperfusion injury in a swine model of hemorrhagic shock
por: Patel, N., et al.
Publicado: (2023)

Role of Smad3 inhibitor and the pyroptosis pathway in spinal cord injury
por: Zhu, Jiajun, et al.
Publicado: (2020)

Delayed Azithromycin Treatment Improves Recovery After Mouse Spinal Cord Injury
por: Kopper, Timothy J., et al.
Publicado: (2019)

Restoring mitochondrial cardiolipin homeostasis reduces cell death and promotes recovery after spinal cord injury
por: Liu, Nai-Kui, et al.
Publicado: (2022)

Delayed microglial depletion after spinal cord injury reduces chronic inflammation and neurodegeneration in the brain and improves neurological recovery in male mice
por: Li, Yun, et al.
Publicado: (2020)

Reaching and Grasping Training Improves Functional Recovery After Chronic Cervical Spinal Cord Injury
por: Gallegos, Chrystine, et al.
Publicado: (2020)

Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice
por: Zhao, Weixing, et al.
Publicado: (2019)

Surgical Considerations to Improve Recovery in Acute Spinal Cord Injury
por: Tabarestani, Troy Q., et al.
Publicado: (2022)

Inhibition of astrocyte hemichannel improves recovery from spinal cord injury
por: Zhang, Chao, et al.
Publicado: (2021)

VX-765 reduces neuroinflammation after spinal cord injury in mice
por: Chen, Jing, et al.
Publicado: (2021)

Nimodipine Promotes Functional Recovery After Spinal Cord Injury in Rats
por: Guo, Fangliang, et al.
Publicado: (2021)

Inhibition of astroglial nuclear factor κB reduces inflammation and improves functional recovery after spinal cord injury
por: Brambilla, Roberta, et al.
Publicado: (2005)

Human immune cells infiltrate the spinal cord and impair recovery after spinal cord injury in humanized mice
por: Carpenter, Randall S., et al.
Publicado: (2019)

Transhemispheric cortex remodeling promotes forelimb recovery after spinal cord injury
por: Wu, Wei, et al.
Publicado: (2022)

Gut dysbiosis impairs recovery after spinal cord injury
por: Kigerl, Kristina A., et al.
Publicado: (2016)

Technology-assisted recovery of walking after spinal cord injury
por: MD, Willis, et al.
Publicado: (2019)

Extrapyramidal plasticity predicts recovery after spinal cord injury
por: Huber, E., et al.
Publicado: (2020)

Alendronate Enhances Functional Recovery after Spinal Cord Injury
por: Choi, Yuna, et al.
Publicado: (2022)

Reorganization of spinal neural circuitry and functional recovery after spinal cord injury
por: Nardone, Raffaele, et al.
Publicado: (2015)

Exogenous platelet-derived growth factor improves neurovascular unit recovery after spinal cord injury
por: Ye, Lu-Xia, et al.
Publicado: (2020)

Endocrine Therapy for the Functional Recovery of Spinal Cord Injury
por: Wang, Hui, et al.
Publicado: (2020)

Improved locomotor recovery after contusive spinal cord injury in Bmal1(−/−) mice is associated with protection of the blood spinal cord barrier
por: Slomnicki, Lukasz P., et al.
Publicado: (2020)

Optogenetic Neuronal Stimulation Promotes Functional Recovery After Spinal Cord Injury
por: Deng, Wei-wei, et al.
Publicado: (2021)

Effects of Elamipretide on Autophagy in Renal Cells of Pigs with Metabolic Syndrome
por: Hong, Siting, et al.
Publicado: (2022)

Elamipretide effects on the skeletal muscle phosphoproteome in aged female mice
por: Campbell, Matthew D., et al.
Publicado: (2022)

Brain-controlled modulation of spinal circuits improves recovery from spinal cord injury
por: Bonizzato, Marco, et al.
Publicado: (2018)

Vagus Nerve Stimulation Reduces Neuroinflammation Through Microglia Polarization Regulation to Improve Functional Recovery After Spinal Cord Injury
por: Chen, Hui, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_p3citut61jg06it86jb7k32jje