Inhibition of pro-inflammatory signaling in human primary macrophages by enhancing arginase-2 via target site blockers

The modulation of macrophage phenotype from a pro-inflammatory to an anti-inflammatory state holds therapeutic potential in the treatment of inflammatory disease. We have previously shown that arginase-2 (Arg2), a mitochondrial enzyme, is a key regulator of the macrophage anti-inflammatory response....

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Detalles Bibliográficos
Autores principales: Fitzsimons, Stephen, Muñoz-San Martín, María, Nally, Frances, Dillon, Eugene, Fashina, Ifeolutembi A., Strowitzki, Moritz J., Ramió-Torrentà, Lluís, Dowling, Jennifer K., De Santi, Chiara, McCoy, Claire E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10494319/
https://www.ncbi.nlm.nih.gov/pubmed/37701067
http://dx.doi.org/10.1016/j.omtn.2023.08.023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10494319/
https://www.ncbi.nlm.nih.gov/pubmed/37701067
http://dx.doi.org/10.1016/j.omtn.2023.08.023

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