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Inhibition of pro-inflammatory signaling in human primary macrophages by enhancing arginase-2 via target site blockers
The modulation of macrophage phenotype from a pro-inflammatory to an anti-inflammatory state holds therapeutic potential in the treatment of inflammatory disease. We have previously shown that arginase-2 (Arg2), a mitochondrial enzyme, is a key regulator of the macrophage anti-inflammatory response....
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10494319/ https://www.ncbi.nlm.nih.gov/pubmed/37701067 http://dx.doi.org/10.1016/j.omtn.2023.08.023 |