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H3K18 lactylation of senescent microglia potentiates brain aging and Alzheimer's disease through the NFκB signaling pathway

Cellular senescence serves as a fundamental and underlying activity that drives the aging process, and it is intricately associated with numerous age-related diseases, including Alzheimer's disease (AD), a neurodegenerative aging-related disorder characterized by progressive cognitive impairmen...

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Detalles Bibliográficos
Autores principales: Wei, Lin, Yang, Xiaowen, Wang, Jie, Wang, Zhixiao, Wang, Qiguang, Ding, Yan, Yu, Aiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10494370/
https://www.ncbi.nlm.nih.gov/pubmed/37697347
http://dx.doi.org/10.1186/s12974-023-02879-7