Cargando…

H3K18 lactylation of senescent microglia potentiates brain aging and Alzheimer's disease through the NFκB signaling pathway

Cellular senescence serves as a fundamental and underlying activity that drives the aging process, and it is intricately associated with numerous age-related diseases, including Alzheimer's disease (AD), a neurodegenerative aging-related disorder characterized by progressive cognitive impairmen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wei, Lin, Yang, Xiaowen, Wang, Jie, Wang, Zhixiao, Wang, Qiguang, Ding, Yan, Yu, Aiqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10494370/ https://www.ncbi.nlm.nih.gov/pubmed/37697347 http://dx.doi.org/10.1186/s12974-023-02879-7

Ejemplares similares

H3K18 lactylation marks tissue-specific active enhancers
por: Galle, Eva, et al.
Publicado: (2022)

Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia
por: Han, Hao, et al.
Publicado: (2023)

Lactylated Histone H3K18 as a Potential Biomarker for the Diagnosis and Predicting the Severity of Septic Shock
por: Chu, Xin, et al.
Publicado: (2022)

YY1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2
por: Wang, Xiaotang, et al.
Publicado: (2023)

Potential biomarker for diagnosis and therapy of sepsis: Lactylation
por: Sun, ZeXian, et al.
Publicado: (2023)

Identification of lysine-lactylated substrates in gastric cancer cells
por: Yang, Dawei, et al.
Publicado: (2022)

Effect of lactylation on functional and structural properties of gluten
por: Wang, Yu, et al.
Publicado: (2022)

Comprehensive analysis of lysine lactylation in Frankliniella occidentalis
por: An, Dong, et al.
Publicado: (2022)

Functions and mechanisms of lactylation in carcinogenesis and immunosuppression
por: Su, Jing, et al.
Publicado: (2023)

Metabolic regulation of gene expression by histone lactylation
por: Zhang, Di, et al.
Publicado: (2019)

Microglia promote autoimmune inflammation via the noncanonical NF-κB pathway
por: Jie, Zuliang, et al.
Publicado: (2021)

Lactylation: a Passing Fad or the Future of Posttranslational Modification
por: Xin, Qi, et al.
Publicado: (2022)

NF-κB in Cellular Senescence and Cancer Treatment
por: Jing, Hua, et al.
Publicado: (2014)

Global lactylome reveals lactylation-dependent mechanisms underlying T(H)17 differentiation in experimental autoimmune uveitis
por: Fan, Wei, et al.
Publicado: (2023)

The role and mechanism of histone lactylation in health and diseases
por: Xie, Yumei, et al.
Publicado: (2022)

Physicochemical characterization of sodium stearoyl lactylate (SSL), polyoxyethylene sorbitan monolaurate (Tween 20) and κ-carrageenan
por: Ortiz-Tafoya, M.C., et al.
Publicado: (2018)

Systematic identification of the lysine lactylation in the protozoan parasite Toxoplasma gondii
por: Zhao, Wei, et al.
Publicado: (2022)

Quantitative characterization and analysis of the dynamic NF-κB response in microglia
por: Sheppard, Patrick W, et al.
Publicado: (2011)

Lactylation of PKM2 Suppresses Inflammatory Metabolic Adaptation in Pro-inflammatory Macrophages
por: Wang, Jizhuang, et al.
Publicado: (2022)

Senescence and NFκB: A trojan horse in tumors?
por: Crescenzi, Elvira, et al.
Publicado: (2012)

TREM2 inhibits inflammatory responses in mouse microglia by suppressing the PI3K/NF‐κB signaling
por: Li, Caixia, et al.
Publicado: (2018)

Aβ promotes CD38 expression in senescent microglia in Alzheimer’s disease
por: Hu, Yiran, et al.
Publicado: (2022)

Biosynthesis of Chlorinated Lactylates in Sphaerospermopsis sp. LEGE 00249
por: Abt, Kathleen, et al.
Publicado: (2021)

Lactate-Lactylation Hands between Metabolic Reprogramming and Immunosuppression
por: Chen, Lihua, et al.
Publicado: (2022)

The function and mechanism of lactate and lactylation in tumor metabolism and microenvironment
por: Zhang, Yan, et al.
Publicado: (2022)

Global Analysis of Lysine Lactylation of Germinated Seeds in Wheat
por: Zhu, Junke, et al.
Publicado: (2023)

The 18 kDa Translocator Protein, Microglia and Neuroinflammation
por: Liu, Guo‐Jun, et al.
Publicado: (2014)

Sodium aescinate inhibits microglia activation through NF-κB pathway and exerts neuroprotective effect
por: Xu, Fei, et al.
Publicado: (2023)

YiaC and CobB regulate lysine lactylation in Escherichia coli
por: Dong, Hanyang, et al.
Publicado: (2022)

Lactate and Lactylation: Clinical Applications of Routine Carbon Source and Novel Modification in Human Diseases
por: Wang, Zhimin, et al.
Publicado: (2023)

Artemisinin Attenuates Lipopolysaccharide-Stimulated Proinflammatory Responses by Inhibiting NF-κB Pathway in Microglia Cells
por: Zhu, Cansheng, et al.
Publicado: (2012)

A bioorthogonal chemical reporter for the detection and identification of protein lactylation
por: Sun, Yanan, et al.
Publicado: (2022)

Lactate is a bridge linking glycolysis and autophagy through lactylation
por: Sun, Weixia, et al.
Publicado: (2023)

Histone lactylation regulates cancer progression by reshaping the tumor microenvironment
por: Qu, Junxing, et al.
Publicado: (2023)

Aneuploid senescent cells activate NF‐κB to promote their immune clearance by NK cells
por: Wang, Ruoxi W, et al.
Publicado: (2021)

Lactylation may be a Novel Posttranslational Modification in Inflammation in Neonatal Hypoxic-Ischemic Encephalopathy
por: Zhou, Yue, et al.
Publicado: (2022)

Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis
por: Yang, Kun, et al.
Publicado: (2021)

Candesartan modulates microglia activation and polarization via NF-κB signaling pathway
por: Qie, Shuyan, et al.
Publicado: (2020)

Propofol Suppresses Microglia Inflammation by Targeting TGM2/NF-κB Signaling
por: Hou, Yuanyuan, et al.
Publicado: (2021)

Senescent Microglia: The Key to the Ageing Brain?
por: Greenwood, Eleanor K., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_habo74binjj7hu5541rgnklkde