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Blocking CCN2 Reduces Established Bone Loss Induced by Prolonged Intense Loading by Increasing Osteoblast Activity in Rats

We have an operant model of reaching and grasping in which detrimental bone remodeling is observed rather than beneficial adaptation when rats perform a high‐repetition, high‐force (HRHF) task long term. Here, adult female Sprague–Dawley rats performed an intense HRHF task for 18 weeks, which we hav...

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Detalles Bibliográficos
Autores principales: Lambi, Alex G, Harris, Michele Y, Amin, Mamta, Joiner, Patrice G, Hilliard, Brendan A, Assari, Soroush, Popoff, Steven N, Barbe, Mary F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10494513/
https://www.ncbi.nlm.nih.gov/pubmed/37701153
http://dx.doi.org/10.1002/jbm4.10783