Enhancing solubility and stability of sorafenib through cyclodextrin-based inclusion complexation: in silico and in vitro studies

Sorafenib (SOR) is an oral multikinase inhibitor that effectively hampers the growth and spread of cancer cells by targeting angiogenesis and proliferation. However, SOR tablets (Nexavar) have limited oral bioavailability, ranging from 38% to 49%, due to their low water solubility. To address this i...

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Detalles Bibliográficos
Autores principales: Aman, Aamir, Ali, Saba, Mahalapbutr, Panupong, Krusong, Kuakarun, Wolschann, Peter, Rungrotmongkol, Thanyada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10494890/
https://www.ncbi.nlm.nih.gov/pubmed/37701271
http://dx.doi.org/10.1039/d3ra03867j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10494890/
https://www.ncbi.nlm.nih.gov/pubmed/37701271
http://dx.doi.org/10.1039/d3ra03867j

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