Large-scale phenogenomic analysis of human cancers uncovers frequent alterations affecting SMC5/6 complex components in breast cancer

Cancer cells often experience large-scale alterations in genome architecture because of DNA damage and replication stress. Whether mutations in core regulators of chromosome structure can also lead to cancer-promoting loss in genome stability is not fully understood. To address this question, we con...

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Detalles Bibliográficos
Autores principales: Roy, Shamayita, Zaker, Arvin, Mer, Arvind, D’Amours, Damien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
DNA Damage Sensing and Repair
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495288/
https://www.ncbi.nlm.nih.gov/pubmed/37705607
http://dx.doi.org/10.1093/narcan/zcad047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495288/
https://www.ncbi.nlm.nih.gov/pubmed/37705607
http://dx.doi.org/10.1093/narcan/zcad047

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