Fc-engineered monoclonal antibodies to reduce off-target liver uptake

BACKGROUND: Radiolabeled-antibodies usually display non-specific liver accumulation that may impair image analysis and antibody biodistribution. Here, we investigated whether Fc silencing influenced antibody biodistribution. We compared recombinant (89)Zr-labeled antibodies (human IgG1 against diffe...

Descripción completa

Detalles Bibliográficos
Autores principales: Mangeat, Tristan, Gracia, Matthieu, Pichard, Alexandre, Poty, Sophie, Martineau, Pierre, Robert, Bruno, Deshayes, Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Preliminary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495296/
https://www.ncbi.nlm.nih.gov/pubmed/37697076
http://dx.doi.org/10.1186/s13550-023-01030-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495296/
https://www.ncbi.nlm.nih.gov/pubmed/37697076
http://dx.doi.org/10.1186/s13550-023-01030-0

Ejemplares similares