Single-molecule imaging reveals distinct elongation and frameshifting dynamics between frames of expanded RNA repeats in C9ORF72-ALS/FTD

C9ORF72 hexanucleotide repeat expansion is the most common genetic cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). One pathogenic mechanism is the accumulation of toxic dipeptide repeat (DPR) proteins like poly-GA, GP and GR, produced by the noncanonical translat...

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Detalles Bibliográficos
Autores principales: Latallo, Malgorzata J., Wang, Shaopeng, Dong, Daoyuan, Nelson, Blake, Livingston, Nathan M., Wu, Rong, Zhao, Ning, Stasevich, Timothy J., Bassik, Michael C., Sun, Shuying, Wu, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495369/
https://www.ncbi.nlm.nih.gov/pubmed/37696852
http://dx.doi.org/10.1038/s41467-023-41339-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495369/
https://www.ncbi.nlm.nih.gov/pubmed/37696852
http://dx.doi.org/10.1038/s41467-023-41339-x

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