A split and inducible adenine base editor for precise in vivo base editing

DNA base editors use deaminases fused to a programmable DNA-binding protein for targeted nucleotide conversion. However, the most widely used TadA deaminases lack post-translational control in living cells. Here, we present a split adenine base editor (sABE) that utilizes chemically induced dimeriza...

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Detalles Bibliográficos
Autores principales: Zeng, Hongzhi, Yuan, Qichen, Peng, Fei, Ma, Dacheng, Lingineni, Ananya, Chee, Kelly, Gilberd, Peretz, Osikpa, Emmanuel C., Sun, Zheng, Gao, Xue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495389/
https://www.ncbi.nlm.nih.gov/pubmed/37696818
http://dx.doi.org/10.1038/s41467-023-41331-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495389/
https://www.ncbi.nlm.nih.gov/pubmed/37696818
http://dx.doi.org/10.1038/s41467-023-41331-5

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