Geometric alignment of aminoacyl-tRNA relative to catalytic centers of the ribosome underpins accurate mRNA decoding

Accurate protein synthesis is determined by the two-subunit ribosome’s capacity to selectively incorporate cognate aminoacyl-tRNA for each mRNA codon. The molecular basis of tRNA selection accuracy, and how fidelity can be affected by antibiotics, remains incompletely understood. Using molecular sim...

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Detalles Bibliográficos
Autores principales: Girodat, Dylan, Wieden, Hans-Joachim, Blanchard, Scott C., Sanbonmatsu, Karissa Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495418/
https://www.ncbi.nlm.nih.gov/pubmed/37696823
http://dx.doi.org/10.1038/s41467-023-40404-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495418/
https://www.ncbi.nlm.nih.gov/pubmed/37696823
http://dx.doi.org/10.1038/s41467-023-40404-9

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