Extracellular calcium functions as a molecular glue for transmembrane helices to activate the scramblase Xkr4

The “eat me” signal, phosphatidylserine is exposed on the surface of dying cells by phospholipid scrambling. Previously, we showed that the Xkr family protein Xkr4 is activated by caspase-mediated cleavage and binding of the XRCC4 fragment. Here, we show that extracellular calcium is an additional f...

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Detalles Bibliográficos
Autores principales: Zhang, Panpan, Maruoka, Masahiro, Suzuki, Ryo, Katani, Hikaru, Dou, Yu, Packwood, Daniel M., Kosako, Hidetaka, Tanaka, Motomu, Suzuki, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495444/
https://www.ncbi.nlm.nih.gov/pubmed/37696806
http://dx.doi.org/10.1038/s41467-023-40934-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495444/
https://www.ncbi.nlm.nih.gov/pubmed/37696806
http://dx.doi.org/10.1038/s41467-023-40934-2

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