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Extracellular calcium functions as a molecular glue for transmembrane helices to activate the scramblase Xkr4
The “eat me” signal, phosphatidylserine is exposed on the surface of dying cells by phospholipid scrambling. Previously, we showed that the Xkr family protein Xkr4 is activated by caspase-mediated cleavage and binding of the XRCC4 fragment. Here, we show that extracellular calcium is an additional f...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495444/ https://www.ncbi.nlm.nih.gov/pubmed/37696806 http://dx.doi.org/10.1038/s41467-023-40934-2 |