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Purification and Characterization of Mitochondrial Mg(2+)-Independent Sphingomyelinase from Rat Brain
Sphingomyelinase (SMase) catalyzes ceramide production from sphingomyelin. Ceramides are critical in cellular responses such as apoptosis. They enhance mitochondrial outer membrane permeabilization (MOMP) through self-assembly in the mitochondrial outer membrane to form channels that release cytochr...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society for Molecular and Cellular Biology
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495687/ https://www.ncbi.nlm.nih.gov/pubmed/37305954 http://dx.doi.org/10.14348/molcells.2023.0074 |