Palladium-Catalyzed Asymmetric Conjugate Addition of Arylboronic Acids to α,β-Unsaturated Lactams: Enantioselective Construction of All-Carbon Quaternary Stereocenters in Saturated Nitrogen-Containing Heterocycles

[Image: see text] Stereogenic nitrogen-containing heterocycles are ubiquitous in natural products and pharmaceutical compounds, but methods for their enantioselective construction have remained elusive. We report a general method for the asymmetric conjugate addition of arylboronic acids to β-alkyl/...

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Detalles Bibliográficos
Autores principales: Zhang, Tianyi, Nishiura, Yuji, Cusumano, Alexander Q., Stoltz, Brian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10496148/
https://www.ncbi.nlm.nih.gov/pubmed/37639656
http://dx.doi.org/10.1021/acs.orglett.3c02064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10496148/
https://www.ncbi.nlm.nih.gov/pubmed/37639656
http://dx.doi.org/10.1021/acs.orglett.3c02064

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