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Squalene epoxidase/SQLE is a candidate target for treatment of colorectal cancers with p53 mutation and elevated c-MYC expression

Elevated expression of c-MYC and inactivation of p53 represent two of the most common alterations in colorectal cancer (CRC). However, c-MYC and defective p53 are difficult to target therapeutically. Therefore, effectors downstream of both c-MYC and p53 may represent attractive, alternative targets...

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Detalles Bibliográficos
Autores principales: Du, Yuyun, Rokavec, Matjaz, Hermeking, Heiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10496509/
https://www.ncbi.nlm.nih.gov/pubmed/37705742
http://dx.doi.org/10.7150/ijbs.85724