Structure of the voltage-gated potassium channel K(V)1.3: Insights into the inactivated conformation and binding to therapeutic leads

The voltage-gated potassium channel K(V)1.3 is an important therapeutic target for the treatment of autoimmune and neuroinflammatory diseases. The recent structures of K(V)1.3, Shaker-IR (wild-type and inactivating W434F mutant) and an inactivating mutant of rat K(V)1.2-K(V)2.1 paddle chimera (K(V)C...

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Detalles Bibliográficos
Autores principales: Chandy, K. George, Sanches, Karoline, Norton, Raymond S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Ion Channel Structure
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10496531/
https://www.ncbi.nlm.nih.gov/pubmed/37695839
http://dx.doi.org/10.1080/19336950.2023.2253104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10496531/
https://www.ncbi.nlm.nih.gov/pubmed/37695839
http://dx.doi.org/10.1080/19336950.2023.2253104

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