Cargando…

Functional interactomes of the Ebola virus polymerase identified by proximity proteomics in the context of viral replication

Ebola virus (EBOV) critically depends on the viral polymerase to replicate and transcribe the viral RNA genome in the cytoplasm of host cells, where cellular factors can antagonize or facilitate the virus life cycle. Here we leverage proximity proteomics and conduct a small interfering RNA (siRNA) s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fang, Jingru, Pietzsch, Colette, Tsaprailis, George, Crynen, Gogce, Cho, Kelvin Frank, Ting, Alice Y., Bukreyev, Alexander, de la Torre, Juan Carlos, Saphire, Erica Ollmann
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10496643/ https://www.ncbi.nlm.nih.gov/pubmed/35320713 http://dx.doi.org/10.1016/j.celrep.2022.110544

Ejemplares similares

Proximity interactome analysis of Lassa polymerase reveals eRF3a/GSPT1 as a druggable target for host-directed antivirals
por: Fang, Jingru, et al.
Publicado: (2022)

Spatial and functional arrangement of Ebola virus polymerase inside phase-separated viral factories
por: Fang, Jingru, et al.
Publicado: (2023)

Antibody Repertoires to the Same Ebola Vaccine Antigen Are Differentially Affected by Vaccine Vectors
por: Meyer, Michelle, et al.
Publicado: (2018)

Staufen1 Interacts with Multiple Components of the Ebola Virus Ribonucleoprotein and Enhances Viral RNA Synthesis
por: Fang, Jingru, et al.
Publicado: (2018)

The Ebola Virus VP30-NP Interaction Is a Regulator of Viral RNA Synthesis
por: Kirchdoerfer, Robert N., et al.
Publicado: (2016)

Short-Term and Long-Term Sensitization Differentially Alters the Composition of an Anterograde Transport Complex in Aplysia
por: Sadhu, Abhishek, et al.
Publicado: (2023)

Ebola Virus Glycoprotein Needs an Additional Trigger, beyond Proteolytic Priming for Membrane Fusion
por: Bale, Shridhar, et al.
Publicado: (2011)

Identification of the RNA polymerase I-RNA interactome
por: Piñeiro, David, et al.
Publicado: (2018)

Ebola and Marburg virus matrix layers are locally ordered assemblies of VP40 dimers
por: Wan, William, et al.
Publicado: (2020)

Novel attempts launched toward universal Sarbecovirus vaccine
por: Li, Haoyang, et al.
Publicado: (2021)

Development and Structural Analysis of Antibody Therapeutics for Filoviruses
por: Yu, Xiaoying, et al.
Publicado: (2022)

Lassa virus glycoprotein: stopping a moving target
por: Hastie, Kathryn M, et al.
Publicado: (2018)

Lifted Up from Lockdown
por: Arturo, Emilia C., et al.
Publicado: (2020)

Ebola Virus NP Binding to Host Protein Phosphatase-1 Regulates Capsid Formation
por: Ahmad, Asrar, et al.
Publicado: (2023)

Targeting the Non-catalytic RVxF Site of Protein Phosphatase-1 With Small Molecules for Ebola Virus Inhibition
por: Lin, Xionghao, et al.
Publicado: (2019)

The Ebola Virus Interferon Antagonist VP24 Directly Binds STAT1 and Has a Novel, Pyramidal Fold
por: Zhang, Adrianna P. P., et al.
Publicado: (2012)

Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies
por: Bornholdt, Zachary A., et al.
Publicado: (2016)

Correction: The Ebola Virus Interferon Antagonist VP24 Directly Binds STAT1 and Has a Novel, Pyramidal Fold
por: Zhang, Adrianna P. P., et al.
Publicado: (2013)

Species-Specific Evolution of Ebola Virus during Replication in Human and Bat Cells
por: Whitfield, Zachary J., et al.
Publicado: (2020)

Cellular mRNA triggers structural transformation of Ebola virus matrix protein VP40 to its essential regulatory form
por: Landeras-Bueno, Sara, et al.
Publicado: (2021)

Plasmodium infection disrupts the T follicular helper cell response to heterologous immunization
por: Fontana, Mary F, et al.
Publicado: (2023)

An Upstream Open Reading Frame Modulates Ebola Virus Polymerase Translation and Virus Replication
por: Shabman, Reed S., et al.
Publicado: (2013)

Proteomic Identification of Pathways Responsible for the Estradiol Therapeutic Window in AD Animal Models
por: Cui, Jie, et al.
Publicado: (2019)

Structures of Ebola Virus GP and sGP in Complex with Therapeutic Antibodies
por: Pallesen, Jesper, et al.
Publicado: (2016)

Disabling of lymphocyte immune response by Ebola virus
por: Younan, Patrick, et al.
Publicado: (2018)

Proteomics studies of the interactome of RNA polymerase II C-terminal repeated domain
por: Pineda, Gabriel, et al.
Publicado: (2015)

Topoisomerase II Inhibitors Induce DNA Damage-Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion
por: Luthra, Priya, et al.
Publicado: (2017)

Identification of the Bok Interactome Using Proximity Labeling
por: Szczesniak, Laura M., et al.
Publicado: (2021)

Global Proximity Interactome of the Human Macroautophagy Pathway
por: Tu, Yi Xin (Iris), et al.
Publicado: (2021)

Deciphering inhibitory mechanism of coronavirus replication through host miRNAs-RNA-dependent RNA polymerase interactome
por: Morenikeji, Olanrewaju B., et al.
Publicado: (2022)

The N-cadherin interactome in primary cardiomyocytes as defined using quantitative proximity proteomics
por: Li, Yang, et al.
Publicado: (2019)

Structure of the Ebola virus polymerase complex
por: Yuan, Bin, et al.
Publicado: (2022)

BROADLY NEUTRALIZING ANTIBODIES FROM HUMAN SURVIVORS TARGET A CONSERVED SITE IN THE EBOLA VIRUS GLYCOPROTEIN HR2/MPER REGION
por: Flyak, Andrew I., et al.
Publicado: (2018)

Identification of Myelin Basic Protein Proximity Interactome Using TurboID Labeling Proteomics
por: Smirnova, Evgeniya V., et al.
Publicado: (2023)

In vivo interactome profiling by enzyme‐catalyzed proximity labeling
por: Xu, Yangfan, et al.
Publicado: (2021)

Real-time digital polymerase chain reaction (PCR) as a novel technology improves limit of detection for rare allele assays
por: Xu, Jiachen, et al.
Publicado: (2021)

Hiding the evidence: two strategies for innate immune evasion by hemorrhagic fever viruses
por: Hastie, Kathryn M, et al.
Publicado: (2012)

SnapShot: Enveloped Virus Entry
por: Mercer, Jason, et al.
Publicado: (2020)

Structural Basis for the dsRNA Specificity of the Lassa Virus NP Exonuclease
por: Hastie, Kathryn M., et al.
Publicado: (2012)

Structure of the Inmazeb cocktail and resistance to Ebola virus escape
por: Rayaprolu, Vamseedhar, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_50jpmj9jijo9c4kekls075s2ll