Dynamical modeling of proliferative-invasive plasticity and IFNγ signaling in melanoma reveals mechanisms of PD-L1 expression heterogeneity

BACKGROUND: Phenotypic heterogeneity of melanoma cells contributes to drug tolerance, increased metastasis, and immune evasion in patients with progressive disease. Diverse mechanisms have been individually reported to shape extensive intra-tumor and inter-tumor phenotypic heterogeneity, such as IFN...

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Detalles Bibliográficos
Autores principales: Subhadarshini, Seemadri, Sahoo, Sarthak, Debnath, Shibjyoti, Somarelli, Jason A, Jolly, Mohit Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10496669/
https://www.ncbi.nlm.nih.gov/pubmed/37678920
http://dx.doi.org/10.1136/jitc-2023-006766

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10496669/
https://www.ncbi.nlm.nih.gov/pubmed/37678920
http://dx.doi.org/10.1136/jitc-2023-006766

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