Cargando…

m(6)A methyltransferase METTL16 mediates immune evasion of colorectal cancer cells via epigenetically regulating PD-L1 expression

Background: The immune checkpoint inhibitors (ICIs) has dramatically changed the therapeutic area of cancers. A great number of patients with CRC exhibit poor response rate to ICI treatment. N6-methyl adenosine (m6A) is closely correlated with the initiation and progression of cancers. To explore th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Ailei, Sun, Yingjie, Wang, Xince, Yan, Zhaofei, Wang, Dongsheng, Zeng, Li, Lu, Qingge
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10496997/ https://www.ncbi.nlm.nih.gov/pubmed/37647025 http://dx.doi.org/10.18632/aging.204980

Ejemplares similares

Efficacy of the Panax Notoginseng Ejiao Suppository in the Treatment of Patients with Ulcerative Proctitis and Its Effect on Inflammatory Response and Immune Function
por: Liu, Yu, et al.
Publicado: (2022)

RNA methyltransferase METTL16: Targets and function
por: Satterwhite, Emily R., et al.
Publicado: (2021)

Structural insights into the RNA methyltransferase domain of METTL16
por: Ruszkowska, Agnieszka, et al.
Publicado: (2018)

Roles of the m6A methyltransferases METTL3, METTL14, and WTAP in pulmonary tuberculosis
por: Zhang, Tian-Ping, et al.
Publicado: (2022)

METTL16, Methyltransferase-Like Protein 16: Current Insights into Structure and Function
por: Ruszkowska, Agnieszka
Publicado: (2021)

Epigenetically modified AP-2α by DNA methyltransferase facilitates glioma immune evasion by upregulating PD-L1 expression
por: Long, Shengwen, et al.
Publicado: (2023)

The Role of the m(6)A RNA Methyltransferase METTL16 in Gene Expression and SAM Homeostasis
por: Mermoud, Jacqueline E.
Publicado: (2022)

m(6)A RNA methyltransferases METTL3/14 regulate immune responses to anti‐PD‐1 therapy
por: Wang, Lingling, et al.
Publicado: (2020)

The m(6)A methyltransferase METTL16 negatively regulates MCP1 expression in mesenchymal stem cells during monocyte recruitment
por: Zhang, Zhaoqiang, et al.
Publicado: (2023)

Novel insights into the m(6)A-RNA methyltransferase METTL3 in cancer
por: Cai, Yiqing, et al.
Publicado: (2021)

The m6A methyltransferase METTL16 inhibits the proliferation of pancreatic adenocarcinoma cancer cells via the p21 signaling pathway
por: Xie, Fuming, et al.
Publicado: (2023)

Crystal structure of human METTL6, the m(3)C methyltransferase
por: Chen, Ran, et al.
Publicado: (2021)

Emerging role of RNA methyltransferase METTL3 in gastrointestinal cancer
por: Wang, Qiang, et al.
Publicado: (2020)

Corrigendum: The m6A methyltransferase METTL16 inhibits the proliferation of pancreatic adenocarcinoma cancer cells via the p21 signaling pathway
por: Xie, Fuming, et al.
Publicado: (2023)

METTL16 promotes glycolytic metabolism reprogramming and colorectal cancer progression
por: Wei, Wei, et al.
Publicado: (2023)

SUMOylation of the m(6)A-RNA methyltransferase METTL3 modulates its function
por: Du, Yuzhang, et al.
Publicado: (2018)

The N(6)-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity
por: Yoshinaga, Masanori, et al.
Publicado: (2022)

RNA Methyltransferase METTL16’s Protein Domains Have Differential Functional Effects on Cell Processes
por: Talic, Emily S., et al.
Publicado: (2023)

Altered Expression of the m6A Methyltransferase METTL3 in Alzheimer’s Disease
por: Huang, He, et al.
Publicado: (2020)

Solution structure of the RNA recognition domain of METTL3-METTL14 N(6)-methyladenosine methyltransferase
por: Huang, Jinbo, et al.
Publicado: (2018)

Comparative Genomics and Functional Studies of Putative m(6)A Methyltransferase (METTL) Genes in Cotton
por: Cao, Junfeng, et al.
Publicado: (2022)

The M6A methyltransferase METTL3: acting as a tumor suppressor in renal cell carcinoma
por: Li, Xiao, et al.
Publicado: (2017)

The Distinct Function and Localization of METTL3/METTL14 and METTL16 Enzymes in Cardiomyocytes
por: Arcidiacono, Orazio Angelo, et al.
Publicado: (2020)

The m6A Methyltransferase METTL3 Is Functionally Implicated in DLBCL Development by Regulating m6A Modification in PEDF
por: Cheng, Yingying, et al.
Publicado: (2020)

The m(6)A methyltransferase METTL3 regulates muscle maintenance and growth in mice
por: Petrosino, Jennifer M., et al.
Publicado: (2022)

m(6)A methyltransferase METTL3 suppresses colorectal cancer proliferation and migration through p38/ERK pathways
por: Deng, Ru, et al.
Publicado: (2019)

RNA m(6)A methyltransferase METTL3 promotes colorectal cancer cell proliferation and invasion by regulating Snail expression
por: Wen, Jianfan, et al.
Publicado: (2021)

The m(6)A RNA methyltransferase METTL3/METTL14 promotes leukemogenesis through the mdm2/p53 pathway in acute myeloid leukemia
por: Sang, Lina, et al.
Publicado: (2022)

The role, mechanism, and application of RNA methyltransferase METTL14 in gastrointestinal cancer
por: Shi, Bin, et al.
Publicado: (2022)

m6A methyltransferase METTL3-induced lncRNA SNHG17 promotes lung adenocarcinoma gefitinib resistance by epigenetically repressing LATS2 expression
por: Zhang, Heng, et al.
Publicado: (2022)

METTL3/YTHDF2 m6A axis accelerates colorectal carcinogenesis through epigenetically suppressing YPEL5
por: Zhou, Dan, et al.
Publicado: (2021)

The Role of RNA Methyltransferase METTL3 in Hepatocellular Carcinoma: Results and Perspectives
por: Pan, Fan, et al.
Publicado: (2021)

Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions
por: Yu, Dan, et al.
Publicado: (2021)

The RNA Methyltransferase Complex of WTAP, METTL3, and METTL14 Regulates Mitotic Clonal Expansion in Adipogenesis
por: Kobayashi, Masatoshi, et al.
Publicado: (2018)

The methyltransferase METTL3 negatively regulates nonalcoholic steatohepatitis (NASH) progression
por: Li, Xinzhi, et al.
Publicado: (2021)

Expression and prognostic potential of ribosome 18S RNA m(6)A methyltransferase METTL5 in gastric cancer
por: Wang, Zhenshuang, et al.
Publicado: (2021)

The RNA methyltransferase METTL16 enhances cholangiocarcinoma growth through PRDM15-mediated FGFR4 expression
por: Liu, Nianli, et al.
Publicado: (2023)

Mutant APC promotes tumor immune evasion via PD-L1 in colorectal cancer
por: Cen, Bo, et al.
Publicado: (2021)

The rRNA m(6)A methyltransferase METTL5 is involved in pluripotency and developmental programs
por: Ignatova, Valentina V., et al.
Publicado: (2020)

Functional Characterization of Two RNA Methyltransferase Genes METTL3 and METTL14 Uncovers the Roles of m(6)A in Mediating Adaptation of Plutella xylostella to Host Plants
por: Wang, Bei-Bei, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_cvldq8qnf0dhkndmnrrau1hdol