Coumarin-chalcone hybrid LM-021 and indole derivative NC009-1 targeting inflammation and oxidative stress to protect BE(2)-M17 cells against α-synuclein toxicity

Parkinson’s disease (PD) is featured mainly by the loss of dopaminergic neurons and the presence of α-synuclein-containing aggregates in the substantia nigra of brain. The α-synuclein fibrils and aggregates lead to increased oxidative stress and neural toxicity in PD. Chronic inflammation mediated b...

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Detalles Bibliográficos
Autores principales: Yang, Pei-Ning, Chen, Wan-Ling, Lee, Jun-Wei, Lin, Chih-Hsin, Chen, Yi-Ru, Lin, Chung-Yin, Lin, Wenwei, Yao, Ching-Fa, Wu, Yih-Ru, Chang, Kuo-Hsuan, Chen, Chiung-Mei, Lee-Chen, Guey-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497001/
https://www.ncbi.nlm.nih.gov/pubmed/37578928
http://dx.doi.org/10.18632/aging.204954

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497001/
https://www.ncbi.nlm.nih.gov/pubmed/37578928
http://dx.doi.org/10.18632/aging.204954

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