A universal method for generating knockout mice in multiple genetic backgrounds using zygote electroporation

Genetically engineered mouse models are essential tools for understanding mammalian gene functions and disease pathogenesis. Genome editing allows the generation of these models in multiple inbred strains of mice without backcrossing. Zygote electroporation dramatically removed the barrier for intro...

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Detalles Bibliográficos
Autores principales: Tamari, Tomohiro, Ikeda, Yoshihisa, Morimoto, Kento, Kobayashi, Keiko, Mizuno-Iijima, Saori, Ayabe, Shinya, Kuno, Akihiro, Mizuno, Seiya, Yoshiki, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Methods & Techniques
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497038/
https://www.ncbi.nlm.nih.gov/pubmed/37623822
http://dx.doi.org/10.1242/bio.059970

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497038/
https://www.ncbi.nlm.nih.gov/pubmed/37623822
http://dx.doi.org/10.1242/bio.059970

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