Modulation of antigen discrimination by duration of immune contacts in a kinetic proofreading model of T cell activation with extreme statistics

T cells form transient cell-to-cell contacts with antigen presenting cells (APCs) to facilitate surface interrogation by membrane bound T cell receptors (TCRs). Upon recognition of molecular signatures (antigen) of pathogen, T cells may initiate an adaptive immune response. The duration of the T cel...

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Detalles Bibliográficos
Autores principales: Morgan, Jonathan, Lindsay, Alan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497171/
https://www.ncbi.nlm.nih.gov/pubmed/37647345
http://dx.doi.org/10.1371/journal.pcbi.1011216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497171/
https://www.ncbi.nlm.nih.gov/pubmed/37647345
http://dx.doi.org/10.1371/journal.pcbi.1011216

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