Sorafenib induces ferroptosis by promoting TRIM54-mediated FSP1 ubiquitination and degradation in hepatocellular carcinoma

BACKGROUND: Ferroptosis is a unique form of regulated cell death that provided a new opportunity for cancer therapy. Ferroptosis suppressor protein 1 (FSP1) is a key regulator in the NAD(P)H/FSP1/CoQ10 antioxidant system, which sever as an oxide redox enzyme to scavenge harmful lipid hydroperoxides...

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Detalles Bibliográficos
Autores principales: Liu, Man-ru, Shi, Ce, Song, Qiu-ya, Kang, Meng-jie, Jiang, Xin, Liu, Hui, Pei, Dong-sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497252/
https://www.ncbi.nlm.nih.gov/pubmed/37695069
http://dx.doi.org/10.1097/HC9.0000000000000246

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497252/
https://www.ncbi.nlm.nih.gov/pubmed/37695069
http://dx.doi.org/10.1097/HC9.0000000000000246

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