Chem-map profiles drug binding to chromatin in cells

Characterizing drug–target engagement is essential to understand how small molecules influence cellular functions. Here we present Chem-map for in situ mapping of small molecules that interact with DNA or chromatin-associated proteins, utilizing small-molecule-directed transposase Tn5 tagmentation....

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Detalles Bibliográficos
Autores principales: Yu, Zutao, Spiegel, Jochen, Melidis, Larry, Hui, Winnie W. I., Zhang, Xiaoyun, Radzevičius, Antanas, Balasubramanian, Shankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497411/
https://www.ncbi.nlm.nih.gov/pubmed/36690761
http://dx.doi.org/10.1038/s41587-022-01636-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497411/
https://www.ncbi.nlm.nih.gov/pubmed/36690761
http://dx.doi.org/10.1038/s41587-022-01636-0

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